Seems obvious but it's not. I've seen this fail presenters at least a dozen times. And at huge events as well.
There're updates for your OS or some piece of software that you depend on for your talk? Here's how it goes - if you don't have the time to run them and then test everything thus ensuring your presentation, demos, etc. were unaffected, don't even bother thinkin about it.
Wait for after the talk.
You will thank me later.